I experienced a very noticeable mini stutters here and there when playing "Witcher 3: The Wild Hunt" on my Windows 10 VM with OVMF and MSI enabled. I was using the official linux-lts-4.1.19-1 from Arch Linux repository. Apparently after changing these 3 kernel configurations and recompile the kernel, the mini stutter issues are gone!
Here are the kernel configuration that I changed:
1.) 1000 MHz clock resolution
2.) Voluntary preemption scheduling
3.) Madvise hugepages (not really sure that this changes anything actually)
I am not really sure whether all or just one of them specifically eliminate the mini stuttering. If someone had any idea what is really going on, my ears are open. I found the kernel config changes from nbhs' early post  and since my VM disk is on ZFS .